The Protein Ontology provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes. Comprehensive curation of experimentally known forms and annotations thereof is expected to expose discrepancies, differences, and gaps in our knowledge. We have annotated the early events of innate immune signaling mediated by Toll-Like Receptor 3 and 4 complexes in human, mouse, and chicken. The resulting ontology and annotation data set has (...) allowed us to identify species-specific gaps in experimental data and possible functional differences between species, and to employ inferred structural and functional relationships to suggest plausible resolutions of these discrepancies and gaps. (shrink)

The influence of personal opinions and biases on scientific conclusions is a threat to the advancement of knowledge. Expertise and experience does not render one immune to this temptation. In this work, one of the founding fathers of statistics, Karl Pearson, is used as an illustration of how even the most talented among us can produce misleading results when inferences are made without caution or reference to potential bias and other analysis limitations. A study performed by Pearson on British Jewish (...) schoolchildren is examined in light of ethical and professional statistical practice. The methodology used and inferences made by Pearson and his coauthor are sometimes questionable and offer insight into how Pearson’s support of eugenics and his own British nationalism could have potentially influenced his often careless and far-fetched inferences. A short background into Pearson’s work and beliefs is provided, along with an in-depth examination of the authors’ overall experimental design and statistical practices. In addition, portions of the study regarding intelligence and tuberculosis are discussed in more detail, along with historical reactions to their work. (shrink)

Photonic Crystals is the first book to address one of the newest and most exciting developments in physics--the discovery of photonic band-gap materials and their use in controlling the propagation of light. Recent discoveries show that many of the properties of an electron in a semiconductor crystal can apply to a particle of light in a photonic crystal. This has vast implications for physicists, materials scientists, and electrical engineers and suggests such possible developments as an entirely optical computer. Combining cutting-edge (...) research with the basic theoretical concepts behind photonic crystals, the authors present to undergraduates and researchers a concise, readable, and comprehensive text on these novel materials and their applications. The first chapters develop the theoretical tools of photonic crystals in a broad, intuitive fashion, starting from nothing more than Maxwell's equations and Fourier analysis, and include analogies to traditional solid-state physics and quantum theory. There follows an investigation of the unique phenomena that take place within photonic crystals, at defect sites, and at surfaces and interfaces. The authors offer a new treatment of the traditional multilayer film (a one-dimensional photonic crystal), which allows for the extension to higher dimensions and more complex geometries. After exploring the capabilities of photonic crystals to guide and localize light, the authors demonstrate how these notions can be put to work. (shrink)

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)

Representing species-specific proteins and protein complexes in ontologies that are both human and machine-readable facilitates the retrieval, analysis, and interpretation of genome-scale data sets. Although existing protin-centric informatics resources provide the biomedical research community with well-curated compendia of protein sequence and structure, these resources lack formal ontological representations of the relationships among the proteins themselves. The Protein Ontology (PRO) Consortium is filling this informatics resource gap by developing ontological representations and relationships among proteins and their variants and modified forms. Because (...) proteins are often functional only as members of stable protein complexes, the PRO Consortium, in collaboration with existing protein and pathway databases, has launched a new initiative to implement logical and consistent representation of protein complexes. We describe here how the PRO Consortium is meeting the challenge of representing species-specific protein complexes, how protein complex representation in PRO supports annotation of protein complexes and comparative biology, and how PRO is being integrated into existing community bioinformatics resources. The PRO resource is accessible at http://pir.georgetown.edu/pro/. (shrink)

Particular visions of urban development are often codified in multi-year resource management policies. These policies, and the negotiations leading to them, are based in specific problem frames and narratives with long legacies. As conditions change and knowledge improves, there is often a need to revisit how problems, opportunities, and development pathways were defined historically, and to consider the viability of alternative pathways for development. In this article, we examine the case of agriculture near Metropolitan Phoenix, in the Central Arizona region, (...) to highlight how frames and narratives embedded in policy can reinforce particular development pathways, even as information, conditions, and values evolve. Using expert interviews and secondary data, we document alternative frames and narratives that may offer different pathways for development and sustainability in the region. By highlighting alternative narratives, we demonstrate the uncertainties and limitations associated with all narratives about development pathways, and explore the possibilities that narrative shifts can alter future outcomes. (shrink)

De nos expériences de conseillères conjugales et familiales, nous avons le sentiment d’un féminin difficile à représenter, comme si les jeunes femmes “zappaient” le féminin pour le maternel. À partir de situations auprès de groupes d’adolescentes et d’adultes, les deux auteures se sont attachées à saisir ce qui vient se dire du féminin chez les jeunes filles et leurs parents. Elles en discutent la spécificité de leurs places en tant que conseillères conjugales et familiales comme créatrices d’un espace de transmission.

Les auteurs, thérapeutes familiaux, rapportent un travail avec une famille pour laquelle la relation d’emprise est le mode singulier et privilégié d’interaction entre les membres. À travers des éléments cliniques, les auteurs montrent comment la relation d’emprise côtoie l’indifférenciation des membres du groupe familial, celle des générations ainsi que la violence qui en découle. Enfin cet écrit montre comment, en utilisant la vulnérabilité des analystes, elle devient vecteur de l’efficacité thérapeutique à travers le transfert et le contre-transfert.

L'article part du fait qui apparaît de plus en plus clairement dans la psychologie américaine moderne de la personnalité, qu’un certain type de domination de la mère dans la famille exerce une influence fâcheuse sur l’évolution psychique des garçons et des filles. L’auteur étudie les diverses interprétations, qu’on peut donner de ce fait.La première interprétation discutée est celle-ci : pour des raisons biologiques, l’amour naturel serait nécessaire à une évolution saine de l’enfant ; l’égoïsme de la mère exercerait une influence (...) nocive parce qu’elle serait en opposition avec cette nécessité biologique. L’article indique que les rapports naturels de la mère et de l’enfant sont, sous bien des rapports, remplacés par des relations culturelles (en particulier pour l’alimentation), ce qui montre l’incertitude de cette interprétation.La deuxième explication discutée est celle-ci : la tendance à dominer l’enfant, à l’élever en vue de succès conformes aux désirs maternels, serait signe du caractère „névrosé“ de la mère, la nocivité de cette conduite serait imputable à la névrose de la mère. Mais, à l’aide des faits ethnologiques, l’article montre qu’une mère agressive, ambitieuse d’autorité n’exerce pas nécessairement une action nocive sur l’évolution du caractère de l’enfant, mais tout au contraire est susceptible de conduire à l’adaptation la meilleure des enfants aux exigences futures de la société.M. Mead présente une troisième explication possible ; l’influence nocive ne tiendrait pas à la structure du caractère de la mère, mais à la contradiction entre le rôle effectif de la mère dans la famille et son rôle officiel dans la société. En Amérique, la mère a pris effectivement la direction dans la famille, cependant il serait entièrement faux de parler d’un matriarcat, puisque cette domination de fait n’a pas de caractère officiel et n’est pas reconnue par la société. Rien n’a été changé à l’organisation patriarcale de la société américaine, mais les formes patriarcales ont été partiellement privées de leur contenu et sont en contradiction avec les rapports de fait à l’intérieur de la famille. On pourrait dire que la mère exerce son autorité à la manière d’un tyran et non d’un maître légitime. Cette forme de pouvoir maternel non contrôlé par les institutions sociales offre un moyen d’expliquer l’influence nocive de ce pouvoir sur les enfants.Der Aufsatz geht von der in der modernen amerikanischen Persönlichkeitsforschung immer evidenter werdenden Tatsache aus, dass ein gewisser Typ der Vorherrschaft der Mutter in der Familie eine schädliche Wirkung auf die seelische Entwicklung von Knaben und Mädchen hat. Die Verfasserin untersucht, welche verschiedenen Interpretationen für diesen Tatbestand möglich sind.Zunächst wird eine Interpretation besprochen, die davon ausgeht, dass aus biologischen Gründen für die gesunde Entwicklung eines Kindes mütterliche Liebe notwendig ist und dass aus dem Gegensatz zu dieser biologischen Notwendigkeit heraus die egoistische Mutter einen schädlichen Einfluss darstellt. Durch den Hinweis darauf, dass die „natürliche“ Beziehung zwischen Mutter und Kind in vielen anderen Hinsichten durch kulturelle ersetzt werde, speziell in der Ernährung, wird die Fragwürdigkeit dieses Gesichtspunktes begründet.Dann wird die Erklärung diskutiert, nach der die Tendenz, das Kind zu beherrschen und gewaltsam zu im Sinne der Mutter liegenden Erfolgen anzutreiben, ein Symptom des neurotischen Charakters der Mutter und die Schädlichkeit dieses Verhaltens eben in der Neurose der Mutter zu suchen sei. Es wird an ethnologischem Material gezeigt, dass eine aggressive und herrschsüchtige Charakterstruktur der Mutter nicht notwendigerweise schädliche Wirkungen auf die Charakterentwicklung der Kinder hat, sondern ganz im Gegenteil zur optimalen Anpassung der Kinder an die sie später erwartenden gesellschaftlichen Anforderungen führen kann.M. Mead legt eine dritte Erklärungsmöglichkeit vor : dass der schädliche Einfluss nicht in der Charakterstruktur der Mutter an sich zu suchen ist, sondern in dem Widerspruch zwischen der faktischen Rolle der Mutter in der Familie und ihrer „offiziellen“ Rolle in der Gesellschaft. Während die amerikanische Mutter häufig tatsächlich die Herrschaft in der Familie an sich gerissen hat, wäre es doch ganz falsch, von einem Matriarchat in Amerika zu sprechen, da die faktische Herrschaft in der Familie in keiner Weise den Charakter einer offiziellen und gesellschaftlich anerkannten Herrschaft der Frau angenommen hat. Vielmehr hat sich an der patriarchalischen Organisation der amerikanischen Gesellschaft nichts Entscheidendes geändert, aber die patriarchalischen Formen sind zum Teil ihres Inhaltes beraubt worden und stehen im Gegensatz zu den faktischen Verhältnissen in der Familie. Die Mutter übt ihre Herrschaft gleichsam nicht als ein rechtmässiger Herrscher, sondern als ein Tyrann aus. In dieser durch gesellschaftliche Institutionen nicht kontrollierten Form mütterlicher Herrschaft wird eine Erklärungsmöglichkeit für den schädlichen Einfluss dieser Herrschaft auf die Kinder gesehen. (shrink)

There are few living thinkers who have enjoyed the eminence and reown of Jürgen Hamermas. His work has been highly influential not only in philosopy, but also in the fields of politics, sociology and law. This is the first collection dedicated to exploring the connections between his body of work ahd America's most significant philosophical movement, pragmatism. Habermas and Pragmatism considers the influence of pragmatism on Habermas's thought and the tensions between Habermasian social theory and pragmatism. Essays by distinguished pragmatists, (...) legal and critical theorists, and Habermas cover a range of subjects including the philosophy of language, the nature of rationality, democracy, objectivity, transcendentalism, aesthetics, and law. The collection also addresses the relationship to Habermas of Kant, Peirce, Mead, Dewey, Piaget, Apel, Brandom and Rorty. (shrink)

Placing Goodenough and Deacon’s “From Biology to Consciousness to Morality” against the background of the ethical naturalism of seventeenth- and eighteenth-century British moral theory, Yeager highlights the contribution the authors make to the moral sense tradition as well as indicating the limitations of such accounts of moral agency, judgment, and conduct. Yeager also identifies two strands of the essay that seem to open toward a more comprehensive account than the authors actually give. The first concerns the “interplay between self-interest and (...) pro-sociality,” and the other concerns the ethical implications of coevolution. On the latter point, the work of G. H. Mead is offered as an illuminating contrast. (shrink)

Few contemporary behaviorists are aware of the importance of George Herbert Mead's contributions to the philosophy of behaviorism. Mead's work on agency and determinism are presented to provide a sample of his ideas on issues that are of significant importance to current debates in behaviorism. His ideas are then compared with Skinner's positions on related issues, revealing significant similarities in their scientific thinking. One major difference between the two behaviorists is identified, and the relative merits of the two different positions (...) are evaluated. If Mead is correct, we can begin to build bridges between the cognitive and the more traditional forms of behaviorism. (shrink)

This paper motivates taking seriously the possibility that brains are basically protean: that they make use of neural structures in inventive, on-the-fly improvisations to suit circumstance and context. Accordingly, we should not always expect cognition to divide into functionally stable neural parts and pieces. We begin by reviewing recent work in cognitive ontology that highlights the inadequacy of traditional neuroscientific approaches when it comes to divining the function and structure of cognition. Cathy J. Price and Karl J. Friston, and (...) Colin Klein identify the limitations of relying on forward and reverse inferences to cast light on the relation between cognitive functions and neural structures. There is reason to prefer Klein’s approach to that of Price and Friston’s. But Klein’s approach is neurocentric - it assumes that we ought to look solely at neural contexts to fix cognitive ontology. Using recent work on mindreading as a case study, we motivate adopting a radically different approach to cognitive ontology. Promoting the Protean Brain Hypothesis, we posit the possibility that we may need to look beyond the brain when deciding which functions are being performed in acts of cognition and in understanding how the brain contributes to such acts by adapting to circumstance. (shrink)

This book is about the eminent behavioral scientist B. F. Skinner, the American culture in which he lived and worked, and the behaviorist movement that played a leading role in American psychological and social thought during the twentieth century. From a base of research on laboratory animals in the 1930s, Skinner built a committed and influential following as well as a utopian movement for social reform. His radical ideas attracted much public attention and generated heated controversy. By the mid-1970s, he (...) had become the most widely recognized scientist in America, surpassing even Margaret Mead and Linus Pauling. Yet Skinner himself was an unassuming family man from a modest middle-class background, a machine-shop tinkerer whose tastes ran to English and French literature. Drawing on archival research, interviews, and historical styles appropriate to the evidence, the authors assembled in this volume examine Skinner's remarkable rise to prominence in the wider context of America's intellectual, cultural, and social history. (shrink)

Bernard Rimé effectively reorients emotions and emotional disclosure in a more social and interpersonal direction, outlining the intricate interplay between emotion generation, emotional sharing, and social integration. However, he also takes a hard line on the intra-psychic emphasis of emotional disclosure, which he frames as the product of an individualistic “Lone Ranger” perspective. In many ways Rimé's critique is on target, but it does not fully credit research and theory demonstrating the benefits of private, self-to-self disclosure. This commentary proposes a (...) reconciliation between Rimé's social structuralist perspective and an intra-psychic, self-based perspective. George Herbert Mead's symbolic interactionism, which suggests that the people can relate to their own selves as with another person, provides the basis for this accord. (shrink)

The author interprets those facets of major American thinkers which resemble, lead to, or complement the insights of Zen; and if a pedantic scholar might quarrel with some of his readings, his own intention and insights are refreshing and provocative. Beginning with Jefferson, and passing through Thoreau, James, Peirce, Santayana, Dewey, and others, he traces the Zen-like themes to their most complete expression in G. M. Mead. In - their regard for non-dualism, participation, responsibility, dynamism, openness, concern for the "everyday," (...) compassion, zest, and being-at-one with self, others, and nature, Ames finds that Zen and American thought meet, and suggests that their differences can be mutually fertilizing. This gentle book is a success in a field too often plagued by non-conformist and cultish postures. --R. C. D. (shrink)

Tenant compte d’une historiographie récente sur les fluides, la sexualité et la santé et constatant la grande timidité des approches de genre dans les dernières synthèses parues sur l’histoire du corps, cet ouvrage collectif, rédigé par douze historiennes, fait le pari d’éclairer à nouveau l’histoire du corps féminin en privilégiant les écoulements sanguins (les « fleurs ») à tous les âges de la vie. Comme l’annoncent Cathy McClive et Nicole Pellegrin en introduction, le but recherché est tri...

Murdoch makes some ambitious claims about love’s epistemic significance which can initially seem puzzling in the light of its heterogeneous and messy everyday manifestations. I provide an interpretation of Murdochian love such that Murdoch’s claims about its epistemic significance can be understood. I argue that Murdoch conceives of love as a virtue, and as belonging at the pinnacle of the hierarchy of the virtues, and that this makes sense of the epistemic role Murdochian love fulfills. Moreover, I suggest that there (...) is good reason to think that Murdochian love is not as far from everyday conceptions of love as it can initially appear. (shrink)

Pour George Herbert Mead, penser c’est entretenir « une conversation de gestes intériorisée». Cette conception ne paraît pas à première vue d’une originalité absolue. Ce qui la rend vraiment originale est l’approche « sociale-behavioriste » dont elle fait partie, et notamment la double idée que la conversation dont il s’agit est une conversation de gestes ou d’attitudes, et que la pensée ainsi quel ‘intelligence réflexive naissent de l’internalisation d’un processus d’organisation de la conduite étayé sur le mécanisme social de la (...) communication. Encore faut-il saisir en quoi cette conception diffère de celle du fondateur de la psychologie behavioriste, John B. Watson, pour qui penser n’est rien d’autre que se tenir un discours interne. (shrink)

Many recent philosophers have been tempted by epistemic partialism. They hold that epistemic norms and those of friendship constitutively conflict. In this paper, I suggest that underpinning this claim is the assumption that friendship is not an epistemically rich state, an assumption that even opponents of epistemic partiality have not questioned. I argue that there is good reason to question this assumption, and instead regard friendship as essentially involving knowledge of the other. If we accept this account of friendship, the (...) possibility of epistemic partialism does not arise. (shrink)

Most of us are partial to our friends and loved ones: we treat them with special care, and we feel justified in doing so. In recent years, the idea that good friends are also epistemically partial to one another has been popular. Being a good friend, so-called epistemic partialists suggest, involves being positively biased towards one's friends – that is, involves thinking more highly of them than is warranted by the evidence. In this paper, I outline the concept of epistemic (...) partiality and its relation to non-epistemic partiality and explore some considerations that speak in favour of and against such partialism in friendships. I finish by suggesting some directions in which this debate could go next. (shrink)

An overview of a philosophical movement originating in the United States of America in the 19th century.

Recent discussions of moral testimony have focused on the acceptability of forming beliefs on the basis of moral testimony, but there has been little acknowledgement of the limits to testimony's capacity to convey moral knowledge. In this paper I outline one such limit, drawing on Iris Murdoch's conception of private moral concepts. Such concepts, I suggest, plausibly play an important role in moral thought, and yet moral knowledge expressed in them cannot be testimonially acquired.

Résumé Ce document examine les liens entre la manière de rendre compte de la réalité sociale esquissée par George Herbert Mead et développée par Beth Singer et la contrepartie que l’on trouve chez les promoteurs du réalisme critique. Que ce soit principalement dans l’optique d’une défense de la pertinence des contributions de Mead ou dans la perspective d’un raffinement de l’ontologie sociale associée au réalisme critique, les auteurs qui ont déjà comparé ces perspectives ont considéré avant tout les différences. Dans (...) cet article, je soutiens qu’il existe des similitudes importantes entre la manière de rendre compte de la collectivité, des normes et des droits chez Mead et Singer et les thèses récentes énoncées de certains partisans du réalisme critique. En outre, je suggère que dans les cas mêmes où les limitations de l’analyse de Mead sont évidentes, par exemple dans sa description par trop « socialisée » du soi, diverses réponses aux critiques peuvent être apportée et plus d’une se trouve en cohérence avec des aspects centraux du réalisme critique. (shrink)